Biomedical Image Processing / Medical Image Processing
Ali Taalimi; Emadoddin Fatemizadeh
Volume 4, Issue 3 , June 2010, , Pages 231-248
Abstract
Functional magnetic resonance imaging (fMRI) is widely used for investigation of brain neural activity. This imaging technique obtains signals and images from human brain’s response to prescheduled tasks. Several studies on blood oxygenation level-dependent (BOLD) signal responses demonstrate nonlinear ...
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Functional magnetic resonance imaging (fMRI) is widely used for investigation of brain neural activity. This imaging technique obtains signals and images from human brain’s response to prescheduled tasks. Several studies on blood oxygenation level-dependent (BOLD) signal responses demonstrate nonlinear behavior in response to a stimulus. In this paper we investigate nonlinear modeling of BOLD signal activity to model the nonlinear and time variant behaviors of this physiological system. For this purpose two categories of nonlinear methods are considered, first those one with emphasis on physiological parameters which affect BOLD response and methods model the input and output of system without any refer to all the hidden state variables (physiological parameters. Balloon model is analzyed and a new approach for activation detection based on this model is introduced. In addition, the Hammerstein-Wiener, NARMA and Volterra kernels are investigated as nonlinear and nonphysiological methods and their ability in detection of activation detection are compared. The Activation detection methods have been applied on the two data sets (real and synthetic). For synthetic data and threshold equal to 0.45, the Jaccard index for Wiener- Hammerstein, NARMA, and Volterra model was 0.9, 1.0, and 0.91, respectively. In real dataset and for optimal threshold (0.35, 0.4, and 0.45) the same index was 0.85, 0.90, and 0.87, respectively.
